Stable isotope-labeled compounds are chemicals enriched with non-radioactive isotopes like ?H, ??C, ??N, or ??O for accurate analytical testing.

They act as internal standards that correct matrix effects and ensure accurate quantification in LC-MS/MS analysis.

No. They contain stable, non-radioactive isotopes, making them safe for research use.

Common isotopes include ?H, ??C, ??N, and ??O due to their stability and compatibility with mass spectrometry.

They mirror analyte behavior, correcting ion suppression and extraction variability for accurate results.

Used in pharmaceuticals, clinical research, metabolomics, biotechnology, forensics, and environmental testing.

A deuterated compound has hydrogen replaced by deuterium (?H), improving its use as an internal standard.

They co-elute with analytes, providing higher precision and reproducibility than external standards.

Isotopic enrichment refers to the percentage of isotope incorporated into the molecule.

They allow pathway tracing, flux analysis, and biomarker identification in metabolomics.

Stable isotopes are safe and non-radioactive; radioactive isotopes emit radiation and need strict regulation.

Typically ?98% purity with high isotopic enrichment for reliable quantification.

Store at 2?8?C or ?20?C, protected from light and moisture.

Yes, SIL compounds are widely used in pharmacokinetic and drug metabolism studies.

They improve accuracy, linearity, precision, and robustness in analytical method validation.

13C avoids chromatographic shifts sometimes seen with deuterium, improving co-elution.

They are more expensive due to complex synthesis but provide superior accuracy.

Yes, custom labeling at specific molecular sites is available.

A SIL-IS is a labeled version of an analyte used for accurate LC-MS/MS quantification.

They mimic analyte behavior, correcting matrix effects and ion suppression.